Chemical Synthesis Letters

Nanoparticles and their Application in Molecular Biology

Rajesh Kumar Meena — Mon, 23 Oct 2023 00:00:00 +0530

Several groups of materials, including inorganic, organic, hybrid, and biological materials, are used to create nanoparticles. Ball milling, vapors deposition, electro spraying, metal salt reduction, sol-gel, coprecipitation, and thermal decomposition are all methods used to create inorganic nanoparticles. By using supercritical solution dialysis, microemulsion, nanoprecipitation, and rapid expansion, organic NPs can be produced. Organic and inorganic materials are used to create hybrid nanoparticles. Several biological nanoparticles, such as lipoproteins, exosomes, ferritin, and viruses, are found in nature. Furthermore, biomolecules including proteins, peptides, and polysaccharides can be used to create nanoparticles. Nanoparticles typically have higher surface-to-volume ratios, superparamagnetism, hardness, Coulomb energy, and catalytic activity than bulk materials do. Nanoparticles are employed in a variety of applications, such as biosensing, drug delivery, bioimaging, catalysis, nano manufacturing, lubrication, electronics, textile production, and water treatment systems. This is because of their distinctive structural, magnetic, mechanical, and electrical capabilities

A review of ionic liquids as a versatile designer-greener solvent

Sharma S, Kailash sharma , Praveen Kumar Sharma — Mon, 23 Oct 2023 00:00:00 +0530

The research into the properties of biodynamic heterosystems has proven to be the most appealing and useful for the development of possible medications with exceptional qualities and that work successfully in the treatment of a wide range of diseases, including pandemics. The synthesis of promising therapeutic materials is quite difficult and requires sufficient time for clinical studies, testing, licenses from relevant authorities, production, and distribution. As a result, researchers typically concentrated on novel approaches’ including a high yield of already approved chemical substances. This review article focuses on the synthesis of medicinally important heterocycles and on sustainable practices green synthesis approaches that incorporate multicomponent processes (MCR), ionic liquids.

Efficient Methodologies for Sustainable Advancements in Chemical Synthesis

Neelima Gupta — Fri, 22 Dec 2023 00:00:00 +0530

Synthesis and in vitro antimicrobial, antiprotozoal and antitumor evaluation of phenothiazine linked 1,2,4-triazoles

Navin B. Patel — Mon, 23 Oct 2023 00:00:00 +0530

Aim: The purpose of this study is to create compounds containing phenothiazine triazoles and test them against various bacterial, fungal, protozoan, and M. tuberculosis H37Rv species. Anti-tumor efficacy is also included.

Background: Phenothiazine comprises two separate hetero atoms, Sulphur and nitrogen, and the 1,2,4-triazoles nucleus has been identified as an antifungal agent with three nitrogen-containing heterocyclic rings. In medicinal chemistry, the nucleus is significant on both counts. Both of these heterocycles are associated in this study with enhancing the therapeutic value.

Objective: Phenothiazine is widely known for its antibacterial, antihistamine, sedative, spasmolytic, and anticancer activities. 1,2,4-triazoles nucleus is the active component of antifungal medications. When these two heterocycles are joined, the biological profile may be improved. The primary goal of this study is to assess the various biological activities of freshly synthesized 1,2,4-triazoles including phenothiazine.

Method: Condensation of 2-chloro-5-(4-hydroxyphenyl)-1-(phenothiazin-10-yl)-ethanone-1 is the method. -2-amino-1,3,4-oxadiazole-2 is then used to create a range of phenothiazine-linked triazoles (5a–m) by reacting with different acid hydrazides. All recently synthesized substances have their structural integrity confirmed using data from IR, ¹H-NMR, ¹³C-NMR, and mass spectrometry. All synthesized substances were evaluated for their antimicrobial, antiprotozoal, and anticancer activities. By connecting the nitrogen of phenothiazine to monocyclic heterocycles like oxadiazole and triazole via the alkyl chain showed significant biological activity of the newly synthesized compounds 5a–m.

Result: Biochemical testing revealed that compounds 1, 2, 3, 5a, 5d, 5e, 5f, 5k, and 5l had antibacterial activity. The antifungal activity of vitamins 5b, 5c, 5d, 5f, and 5k is active. Active against M. tuberculosis are 5d and 5k. In comparison to normal medications, 5a, 5i, 5j, 5k, and 5l showed higher percentages of lysis on T. Cruzi. The anti-tumor effects of 5a, 5j, and 5l were present.

Conclusion: Antibacterial, antifungal, antiprotozoal, and antitumor activities have all been assessed in this study. The majority of recently created compounds have been shown to be biologically active agents. The primary emphasis of this research is the novel compounds' anti-protozoal action

Electronic spectral studies of Pr (III) and Nd (III) with mixed ligand system

Vyas A, Vyas M, Shekhawat M S — Mon, 23 Oct 2023 00:00:00 +0530

Some biprotic acids, namely, salicylic acid, tartaric acid & lactic acid and a few amino acids like glycine andβ-alanine were chosen for mixed ligand system (biprotic acids as primary ligands & amino acids as secondary ligands). These were interacted with metal ion, Pr (III)or Nd (III) in different molar ratios &their electronic absorption spectra were recorded in aqueous solution. The various energy parameters such as Slater-Codon (F_k), Racah (E^k) & Lande(ξ_4f) parameters & intensity parameters such as, oscillator strength (P), Judd-Ofelt parameters (Ω_λ,) have been computed using partial & regression statistical methods. The bonding parameter (b^1/2) & nephelauxetic ratio (β) have also been evaluated to ascertain the covalency in the metal-ligand bond.